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Whilst minimal-count MBL seldom progresses to CLL, large-rely MBL progresses to CLL demanding therapy in a amount of one% to two% per annum. Significant-rely MBL is distinguished from Rai 0 CLL determined by whether the B-cell count is higher than or underneath 5 × 109/L. Whilst persons with the two significant-depend MBL and CLL Rai stage 0 are a